Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder
Chae Yeon Kim, Sunghun Kim, Bo‐yong Park · 2026
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Description
Chae Yeon Kim, Sunghun Kim, and Bo-yong Park split in 2026 autism into subtypes using the left right imbalance of brain activity. Social and communication differences in autism tie closely to brain lateralization, so the team measured how unevenly each brain region sits in the connectivity network. An unsupervised clustering algorithm then grouped autistic participants by their asymmetry patterns.
Three subtypes appeared, differing across movement, control, and default mode networks. One subtype, marked by atypical asymmetry along the sensory to default axis, carried the heaviest clinical severity. The rightward leaning subtype showed underconnection across sensory and association regions and a profile tied to self reference and motivation. The leftward subtype showed overconnection and a profile tied to memory and language systems. The authors argue asymmetry offers a cleaner sorting lens than symptoms alone.
Catalog record
| CREATOR | Chae Yeon Kim, Sunghun Kim, Bo‐yong Park |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36881 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |