Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging
Patrick Bedard, Kristine M Knutson, Patrick M McGurrin, Felipe Vial, Traian Popa, Silvina G Horovitz, Mark Hallett, Avindra Nath, Brian Walitt · 2026
Read Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging by Patrick Bedard, Kristine M Knutson, Patrick M McGurrin, Felipe Vial, Traian Popa, Silvina G Horovitz, Mark Hallett, Avindra Nath, Brian Walitt (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13471709.txt.
Description
Patrick Bedard and colleagues use brain and muscle recordings in 2026 to locate the source of rapid fatigability in myalgic encephalomyelitis, also called chronic fatigue syndrome. Fifteen patients and nineteen matched healthy volunteers squeezed a grip device, holding half their maximum force in alternating half minute blocks. Force, forearm muscle electricity, and brain activity from scalp electrodes and scanners were recorded together, with fatigue onset set person by person.
Patients matched the healthy group on maximum force yet tired much sooner. Healthy volunteers ramped muscle and brain activity up until fatigue, then let it drift down. Patient muscles and brains, by contrast, barely fluctuated across the whole task. The flat central response points the authors toward the brain and its drive signals, rather than the muscle itself, as the seat of fatigability.
Catalog record
| CREATOR | Patrick Bedard, Kristine M Knutson, Patrick M McGurrin, Felipe Vial, Traian Popa, Silvina G Horovitz, Mark Hallett, Avindra Nath, Brian Walitt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |