Prevalence of hyperhomocysteinemia in South Asian patients with heart disease: a systematic review and meta-analysis
Mysha Nowrin Alabbi, Rifah Nanziba, Naila Masfiqua Malek, Nafisa Ahmed, Harisul Hoque, Mahbubul H Siddiqee, Badhan Bhattacharjee, Nadia S Deen · 2026
Read Prevalence of hyperhomocysteinemia in South Asian patients with heart disease: a systematic review and meta-analysis by Mysha Nowrin Alabbi, Rifah Nanziba, Naila Masfiqua Malek, Nafisa Ahmed, Harisul Hoque, Mahbubul H Siddiqee, Badhan Bhattacharjee, Nadia S Deen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13471659.txt.
Description
Alabbi and co-authors pooled studies of hyperhomocysteinemia, excess homocysteine in the blood, among South Asian patients with heart disease. Their 2026 systematic review and meta-analysis gathered 47 articles covering 6,094 patients from India, Pakistan, Bangladesh, and Afghanistan under PRISMA 2020 methods.
The pooled prevalence was striking: 61% of heart disease patients had elevated homocysteine, six in ten, with study estimates swinging widely beneath it. Homocysteine levels ran higher in patients than controls by a standardized difference of 2.22 in the pooled comparison, and Pakistani patients showed the highest concentrations, ahead of Indian and Bangladeshi groups. Study-to-study spread was extreme at I² 98% for prevalence, so the authors rate certainty low and urge tighter primary studies.
Catalog record
| CREATOR | Mysha Nowrin Alabbi, Rifah Nanziba, Naila Masfiqua Malek, Nafisa Ahmed, Harisul Hoque, Mahbubul H Siddiqee, Badhan Bhattacharjee, Nadia S Deen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |