A novel perspective on biomarkers of neurodegeneration and neuroinflammation in first episode psychosis: a cross-sectional study
Valeria Zakurazhnaya, Yana Zorkina, Olga Abramova, Daria Riabinina, Alexandra Ochneva, Valeriya Ushakova, Alexander Reznik, Georgy P. Kostyuk, Anna Morozova · 2026
Read A novel perspective on biomarkers of neurodegeneration and neuroinflammation in first episode psychosis: a cross-sectional study by Valeria Zakurazhnaya, Yana Zorkina, Olga Abramova, Daria Riabinina, Alexandra Ochneva, Valeriya Ushakova, Alexander Reznik, Georgy P. Kostyuk, Anna Morozova (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13471635.txt.
Description
Valeria Zakurazhnaya and colleagues compare in 2026 blood markers of brain degeneration and inflammation across first episode psychosis, chronic schizophrenia, and health. Whether early psychosis is biologically distinct from the chronic illness remains unclear. Eighteen non standard markers were measured in forty nine first episode patients, eighty chronic patients, and eighty healthy volunteers using a multiplex assay.
The first episode group carried a signature the others lacked: lower levels of two markers, higher levels of a cell adhesion molecule, and a building block protein found less often. The chronic group, by contrast, barely differed from healthy controls on most markers. Their marker network was densely interwoven, while first episode patients showed one strong pairing. The authors read early psychosis as its own biological state, not a mild version of the chronic one.
Catalog record
| CREATOR | Valeria Zakurazhnaya, Yana Zorkina, Olga Abramova, Daria Riabinina, Alexandra Ochneva, Valeriya Ushakova, Alexander Reznik, Georgy P. Kostyuk, Anna Morozova |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |