NSUN2/m5C/TPI1 axis promotes glycolysis and immune evasion in breast cancer
Xinming Song, Qihang Li, Ziteng Xiao, Haiqing Luo, Xiangyong Li · 2026
Read NSUN2/m5C/TPI1 axis promotes glycolysis and immune evasion in breast cancer by Xinming Song, Qihang Li, Ziteng Xiao, Haiqing Luo, Xiangyong Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13471626.txt.
Description
Song and co-authors traced how a chemical tag on RNA helps breast cancer cells burn sugar faster and hide from the immune system. Their 2026 study focused on NSUN2, an enzyme that writes m5C marks on RNA, and its target TPI1, a glycolysis enzyme, testing the chain in breast cancer cells and tumor-bearing mice.
Both NSUN2 and TPI1 ran high in breast cancer cells. In patient tissue samples split into groups of 25 high and 25 low expressers, high NSUN2 tracked with larger tumors at a significance of p 0.024 in the correlation table. Silencing NSUN2 slowed cell growth, glycolysis, and immune evasion, while restoring TPI1 reversed every one of those effects. The mechanism ran through the reader protein YBX1 and raised PD-L1, the immune brake, in step.
Catalog record
| CREATOR | Xinming Song, Qihang Li, Ziteng Xiao, Haiqing Luo, Xiangyong Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |