Wireless flexible patch based on ultrasound-responsive SenA@ZIF-8 release for on-demand medication of periodontitis
Bo Peng, Jing Yang, Rui Lin, Yuling Han, Hongning Wang, Runqi Zhou, Tong Yan, Shilin Liu, Hanwei Jiang, Yunshan Li, Tianshu Zhang, Yuhao Peng, Xinyu Xue, Huawei Shen, Jinlin Song, Ximu Zhang · 2026
Read Wireless flexible patch based on ultrasound-responsive SenA@ZIF-8 release for on-demand medication of periodontitis by Bo Peng, Jing Yang, Rui Lin, Yuling Han, Hongning Wang, Runqi Zhou, Tong Yan, Shilin Liu, Hanwei Jiang, Yunshan Li, Tianshu Zhang, Yuhao Peng, Xinyu Xue, Huawei Shen, Jinlin Song, Ximu Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13471616.txt.
Description
Peng and co-authors built a flexible gum patch that uses ultrasound to release an anti-inflammatory drug on demand for periodontitis, the gum disease that loosens teeth. Their 2026 device study loaded senkyunolide A, a plant-derived compound, into ZIF-8 nanoparticles inside a patch whose piezoelectric element turns 1 MHz ultrasound into roughly 10 volts of power.
That power warms a phase-change layer to about 43 degrees Celsius, melting the gate and releasing the drug exactly when triggered. In cell tests the loaded particles protected ligament stem cells from oxidative damage better than free drug and pushed macrophages toward the healing M2 state. In rabbits with induced periodontitis, repeated triggered doses reduced tissue destruction. Nearly 90% of Chinese adults have some periodontitis, the authors note.
Catalog record
| CREATOR | Bo Peng, Jing Yang, Rui Lin, Yuling Han, Hongning Wang, Runqi Zhou, Tong Yan, Shilin Liu, Hanwei Jiang, Yunshan Li, Tianshu Zhang, Yuhao Peng, Xinyu Xue, Huawei Shen, Jinlin Song, Ximu Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |