Copper-EGCG nanoreactor orchestrates dual-metabolic assault and self-amplified cuproptosis for immunogenic prostate cancer therapy
Wenya Li, Xiyao Zhang, Ying Huang, Yangyang Guo, Hao Zhang, Weiying Ge, Yuxin Xie, Yiming Li, Zhen Zhou, Wenjie Ni, Zhe Zheng, Jianmin Li, Yang Zhao · 2026
Read Copper-EGCG nanoreactor orchestrates dual-metabolic assault and self-amplified cuproptosis for immunogenic prostate cancer therapy by Wenya Li, Xiyao Zhang, Ying Huang, Yangyang Guo, Hao Zhang, Weiying Ge, Yuxin Xie, Yiming Li, Zhen Zhou, Wenjie Ni, Zhe Zheng, Jianmin Li, Yang Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13471605.txt.
Description
Li and co-authors built a copper-based nanoreactor that attacks prostate cancer on both of its fuel lines at once. Their 2026 study self-assembled copper ions with EGCG, the green-tea compound, into nanoparticles designed to trigger cuproptosis, a copper-driven cell death, while blocking the sugar-burning backup pathway tumors escape through.
Prostate tumors lean hard on their TCA cycle, the mitochondrial energy loop, which makes them sensitive to copper overload, but they survive by switching to glycolysis. The EGCG half shuts that exit by inhibiting glycolytic enzymes and draining glutathione, the cell's main antioxidant shield. It also downregulates ATP7B, the pump cells use to expel copper, so the metal accumulates irreversibly. The dying cells then matured dendritic cells and flipped macrophages toward the attacking M1 type.
Catalog record
| CREATOR | Wenya Li, Xiyao Zhang, Ying Huang, Yangyang Guo, Hao Zhang, Weiying Ge, Yuxin Xie, Yiming Li, Zhen Zhou, Wenjie Ni, Zhe Zheng, Jianmin Li, Yang Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |