Delayed initiation of GnRH antagonist in PCOS patients undergoing IVF: a retrospective cohort study of premature ovulation and embryological outcomes
Nuri Peker, Ayşen Yücetürk, Esra Tığlı, Özge Karaosmanoğlu, Burak Elmas, İlke Özer Aslan, Bülent Tıraş · 2026
Read Delayed initiation of GnRH antagonist in PCOS patients undergoing IVF: a retrospective cohort study of premature ovulation and embryological outcomes by Nuri Peker, Ayşen Yücetürk, Esra Tığlı, Özge Karaosmanoğlu, Burak Elmas, İlke Özer Aslan, Bülent Tıraş (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13471402.txt.
Description
Peker and colleagues asked whether starting a hormone-blocking drug later in IVF stimulation harms results for women with polycystic ovary syndrome, a common hormone disorder. Their 2026 retrospective study compared 89 patients treated between 2017 and 2025, split by when the blocking drug began. The groups were similar in age and body mass index at the outset.
In the delayed group of 38 patients, injections started only once three follicles reached 17 mm, while the earlier group of 51 started at a single 14 mm follicle. The delayed group had higher estradiol, a hormone that rises with stimulation, when the blocker began, yet embryo outcomes did not suffer for it. Neither blastocyst numbers nor top-grade embryo rates tracked estradiol levels in the correlation analysis.
Catalog record
| CREATOR | Nuri Peker, Ayşen Yücetürk, Esra Tığlı, Özge Karaosmanoğlu, Burak Elmas, İlke Özer Aslan, Bülent Tıraş |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |