Red blood cell-derived extracellular vesicles enable cisplatin and cetuximab combined therapy against triple-negative breast cancer
Miriam Romano, Angelo Musicò, Selene Tassoni, Lucia Paolini, Andrea Zendrini, Enrica Gilberti, Francesca Orlandi, Tatiana Pedrazzi, Silvia Alacqua, Agnese Segala, Rossella Zenatelli, Ingrid Cifola, Eleonora Mangano, Clarissa Consolandi, Tania Camboni, Lorena Signati, Serena Mazzucchelli, Arabella Ne · 2026
Read Red blood cell-derived extracellular vesicles enable cisplatin and cetuximab combined therapy against triple-negative breast cancer by Miriam Romano, Angelo Musicò, Selene Tassoni, Lucia Paolini, Andrea Zendrini, Enrica Gilberti, Francesca Orlandi, Tatiana Pedrazzi, Silvia Alacqua, Agnese Segala, Rossella Zenatelli, Ingrid Cifola, Eleonora Mangano, Clarissa Consolandi, Tania Camboni, Lorena Signati, Serena Mazzucchelli, Arabella Ne (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13471389.txt.
Description
Romano and colleagues built a drug carrier from red blood cell vesicles, tiny bubbles shed by red cells, to deliver two cancer drugs together against triple-negative breast cancer. Their 2026 study loaded the vesicles with cisplatin, a chemotherapy drug, and cetuximab, an antibody drug, and tested the pairing in cells and patient-derived organoids.
Because the vesicles carry no DNA and lack the receptor cetuximab targets, the two drugs did not interfere with each other inside the carrier. The combined formulation boosted cisplatin's cancer-killing power by up to 50% in laboratory tests and in organoids grown from patient tumors. Gene-readout data point to ferroptosis, an iron-driven form of cell death, as part of how the treatment kills tumor cells.
Catalog record
| CREATOR | Miriam Romano, Angelo Musicò, Selene Tassoni, Lucia Paolini, Andrea Zendrini, Enrica Gilberti, Francesca Orlandi, Tatiana Pedrazzi, Silvia Alacqua, Agnese Segala, Rossella Zenatelli, Ingrid Cifola, Eleonora Mangano, Clarissa Consolandi, Tania Camboni, Lorena Signati, Serena Mazzucchelli, Arabella Ne |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 103 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |