Advancing Sustainable Solid-Phase Peptide Synthesis: The Role of 1‑(3-(Dimethylamino)propyl)-3-ethylcarbodiimide Methotosylate (EDC·MeTos) in Green Solvents
Maria Carmina Scala, Martina Landi, Giovanni Vivenzio, Pietro Campiglia, Marina Sala · 2026
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Description
Scala and colleagues published a 2026 study on greener ways to build peptides in the lab. Peptides are short protein chains used in many modern medicines. Their assembly usually swims in a harsh solvent called DMF. The team tested a friendlier solvent mix with a newer coupling reagent.
The mix paired ethyl acetate with a splash of DMSO as the medium. Couplings there matched the purity reached in the standard harsh solvent. The green setup also caused less unwanted flipping of molecule handedness. A helper additive proved useful only for the bulkiest building blocks tested. High-fidelity peptide making without DMF looks viable, the authors conclude. Several model peptides were built to test the system fairly.
Catalog record
| CREATOR | Maria Carmina Scala, Martina Landi, Giovanni Vivenzio, Pietro Campiglia, Marina Sala |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |