Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan
Yung-Tsai Chu, Yu-An Su, Chin-Hsien Lin, Chun-Hwei Tai, Yih-Ru Wu, Chien-Tai Hong, Yu-Wei Chen, Mong-Hsun Tsai, John Hardy, Kin-Ying Mok, Ruey-Meei Wu, East Asian Parkinson Disease Genomics Consortium, Global Parkinson’s Genetics Program · 2026
Read Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan by Yung-Tsai Chu, Yu-An Su, Chin-Hsien Lin, Chun-Hwei Tai, Yih-Ru Wu, Chien-Tai Hong, Yu-Wei Chen, Mong-Hsun Tsai, John Hardy, Kin-Ying Mok, Ruey-Meei Wu, East Asian Parkinson Disease Genomics Consortium, Global Parkinson’s Genetics Program (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13470500.txt.
Description
Yung-Tsai Chu and co-authors map the genetics of Parkinson disease in Taiwan, in a 2026 study. Genetic risk for the disease is poorly charted in East Asian populations, and risk scores built on European data may travel badly. The team assembled over two thousand patients and a similar number of controls, genotyped them on a neuro-focused array, and filled in millions more variants from a Taiwan reference panel.
Strong signals appeared at two known genes, with a closer look suggesting two separate effects at one of them. An East Asian-enriched risk pattern was pinned down, and two known risk variants in another gene were confirmed, with hints that carrying more copies raises risk further. A risk score built from European data separated patients from controls weakly. Adding East Asian and Taiwan-relevant variants improved it. The authors argue for ancestry-aware scores when sorting patients by risk.
Catalog record
| CREATOR | Yung-Tsai Chu, Yu-An Su, Chin-Hsien Lin, Chun-Hwei Tai, Yih-Ru Wu, Chien-Tai Hong, Yu-Wei Chen, Mong-Hsun Tsai, John Hardy, Kin-Ying Mok, Ruey-Meei Wu, East Asian Parkinson Disease Genomics Consortium, Global Parkinson’s Genetics Program |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |