GABRD promotes hepatocellular carcinoma progression via the IL-10RA/JAK2-STAT3 signaling axis
Chengcheng Huang, Weiwei Liu, Zheng Wang, Yingling Liu, Zhenfei Bi, Bin Han, Yue Yan, Shuqi Zhang, Boyu Zhu, Ziyi Zhou, Chaoqun Wang, Lu Zheng, Jing Li · 2026
Read GABRD promotes hepatocellular carcinoma progression via the IL-10RA/JAK2-STAT3 signaling axis by Chengcheng Huang, Weiwei Liu, Zheng Wang, Yingling Liu, Zhenfei Bi, Bin Han, Yue Yan, Shuqi Zhang, Boyu Zhu, Ziyi Zhou, Chaoqun Wang, Lu Zheng, Jing Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13470470.txt.
Description
Huang and colleagues identified in 2026 an unlikely liver cancer driver: GABRD, part of the receptor for GABA, the brain's main calming signal. Liver cancer kills heavily worldwide, with over 900,000 new cases a year and five-year survival near 18 percent. The receptor part ran high in tumors and cell lines, and patients with more fared worse; the team dialed it down and up in cells and mouse models.
The receptor behaved like an accelerator: raising it sped growth, invasion, and movement; removing it slowed all three and shrank mouse tumors. It works by gripping a partner receptor, IL-10RA, switching on the JAK2-STAT3 signaling axis, which drives the shape change letting cancer cells spread. Blocking the axis partly reversed the receptor's tumor effects. The authors establish the three-step chain as an oncogenic driver and nominate GABRD as a therapeutic target for this aggressive cancer.
Catalog record
| CREATOR | Chengcheng Huang, Weiwei Liu, Zheng Wang, Yingling Liu, Zhenfei Bi, Bin Han, Yue Yan, Shuqi Zhang, Boyu Zhu, Ziyi Zhou, Chaoqun Wang, Lu Zheng, Jing Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |