A systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide
Adam J Mulkern, Thu-Hien Vu, Linda Popella, Tobias Kerrinnes, Svetlana Ðurica-Mitić, Manuel Halte, Kylee Dresbach-Hill, Anne-Catrin Uhlemann, Stephan Uphoff, Lars Barquist, Jörg Vogel, Marco Galardini · 2026
Read A systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide by Adam J Mulkern, Thu-Hien Vu, Linda Popella, Tobias Kerrinnes, Svetlana Ðurica-Mitić, Manuel Halte, Kylee Dresbach-Hill, Anne-Catrin Uhlemann, Stephan Uphoff, Lars Barquist, Jörg Vogel, Marco Galardini (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13469510.txt.
Description
The rise of antimicrobial resistance (AMR) among human pathogens is a serious threat to global health, demanding novel treatment strategies. Antibiotics based on programmable antisense oligomers (asobiotics) offer an attractive solution, as their specificity can be quickly updated to target resistant bacteria.
Catalog record
| CREATOR | Adam J Mulkern, Thu-Hien Vu, Linda Popella, Tobias Kerrinnes, Svetlana Ðurica-Mitić, Manuel Halte, Kylee Dresbach-Hill, Anne-Catrin Uhlemann, Stephan Uphoff, Lars Barquist, Jörg Vogel, Marco Galardini |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |