Genome-wide DNA methylation profiling of triple-negative breast cancer uncovers epigenetic biomarkers of tumor identity and the immune microenvironment
Iñaki Sasiain, Deborah F Nacer, Mats Jönsson, Johan Vallon-Christersson, Anita Grigoriadis, Mattias Aine, Johan Staaf · 2026
Read Genome-wide DNA methylation profiling of triple-negative breast cancer uncovers epigenetic biomarkers of tumor identity and the immune microenvironment by Iñaki Sasiain, Deborah F Nacer, Mats Jönsson, Johan Vallon-Christersson, Anita Grigoriadis, Mattias Aine, Johan Staaf (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13469125.txt.
Description
A peer-reviewed research article from Europe PMC (2026). DNA methylation deregulation is an essential feature of tumor biology, influencing cancer formation and pathogenesis. Analyses of DNA methylation in bulk cancer specimens are challenging due to the high data dimensionality, noise, and mixture of different cell types. Here, we characterized methylation dynamics in cancer by investigating the variance structure of bulk tumor DNA methylation data through the identification of groups of highly correlated CpGs, termed CpG cassettes.
Catalog record
| CREATOR | Iñaki Sasiain, Deborah F Nacer, Mats Jönsson, Johan Vallon-Christersson, Anita Grigoriadis, Mattias Aine, Johan Staaf |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |