The changing epidemiology of infection-associated mortality in Alzheimer’s disease in the United States, 1999–2024
Xuemeng Miao, Yingzhi Zhang, Chengtian Gao, Wenjun Meng, Jinhua Yan, Tao Zeng, Guofang Tang · 2026
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Description
Miao and co-authors track a quarter-century of death records in this 2026 study to see how infections contribute to mortality among Americans with Alzheimer's disease. Using the national Multiple Cause of Death database for 1999 through 2024, they sorted infection-linked Alzheimer's deaths into six subtypes. They also modeled trends and gaps between groups, and projected what comes next.
Among more than 2.34 million Alzheimer's-related deaths, 308,045 involved an infection, which works out to 13.2 percent of the total. Overall infection-linked death rates fell by 57.6 percent across the period, led by respiratory infections dropping 68.3 percent in adjusted rate. Genitourinary infections moved the opposite way: their absolute death count rose 75.1 percent, with the steepest growth in rural areas, and deaths concentrated in people aged 85 and older. The authors urge targeted urinary infection prevention as baby boomers enter peak Alzheimer's risk.
Catalog record
| CREATOR | Xuemeng Miao, Yingzhi Zhang, Chengtian Gao, Wenjun Meng, Jinhua Yan, Tao Zeng, Guofang Tang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |