Effects of Chlorine and Methyl Substitution on Structure, IR, and Raman Spectra of the Biomolecule 6-Chloro-3-methyluracil in Isolated and Solid States and in Base-Pair Formation
Mauricio Alcolea Palafox, Nataliya P. Belskaya, Nadya G. Hristova-Avakumova, Irena P. Kostova · 2026
Read Effects of Chlorine and Methyl Substitution on Structure, IR, and Raman Spectra of the Biomolecule 6-Chloro-3-methyluracil in Isolated and Solid States and in Base-Pair Formation by Mauricio Alcolea Palafox, Nataliya P. Belskaya, Nadya G. Hristova-Avakumova, Irena P. Kostova (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13468333.txt.
Description
Palafox and co-authors analyze a chemically tweaked building block of RNA in this 2026 computational and spectroscopic study. Their molecule is 6-chloro-3-methyluracil. It is ordinary uracil with a chlorine atom and a methyl group attached. Those changes raise its chemical reactivity. They make it interesting as a possible drug ingredient.
The team measured the molecule's infrared and Raman spectra in solid form. They matched the readings against quantum-chemical calculations. The models covered the isolated molecule, a three-molecule crystal, and the molecule inside a short double-stranded RNA helix. Swapping the modified base into the helix in place of uracil noticeably deformed the structure. That hints it could interfere with cancer-related or viral RNA. Computer docking also suggested the molecule fits the active site of a protein complex. The complex involves beta-catenin, a known cancer target.
Catalog record
| CREATOR | Mauricio Alcolea Palafox, Nataliya P. Belskaya, Nadya G. Hristova-Avakumova, Irena P. Kostova |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 123 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |