The impact of ustekinumab and tumor necrosis factor antagonists on extraintestinal manifestations of Crohn’s disease: a systematic review and meta-analysis
Mao-xuan Lin, Ye-xin Chen, Tu-nan Ding, Wei Han, Mo-han Sun, Yi-yu Dong, Zi-qing Zheng, Yan Zhao, Yi-wen Hu, Run-dong Yu, Yao-fu Zhang, Jun Xu · 2026
Read The impact of ustekinumab and tumor necrosis factor antagonists on extraintestinal manifestations of Crohn’s disease: a systematic review and meta-analysis by Mao-xuan Lin, Ye-xin Chen, Tu-nan Ding, Wei Han, Mo-han Sun, Yi-yu Dong, Zi-qing Zheng, Yan Zhao, Yi-wen Hu, Run-dong Yu, Yao-fu Zhang, Jun Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13467844.txt.
Description
Lin and a large team compare two drug classes for Crohn's disease symptoms that appear outside the gut, in this 2026 systematic review and meta-analysis. Such symptoms include joint pain, skin problems, and fatigue. They pooled randomized controlled trials of ustekinumab, a newer antibody drug, against the older tumor necrosis factor blockers that doctors usually try first.
Twenty-three trials covering 7,810 adults with moderate-to-severe Crohn's disease met the criteria. Ustekinumab cut the rate of fatigue substantially. Its pooled incidence rate ratio was 0.53 against control treatment in the pooled trials. During maintenance therapy it also reduced arthritis and joint pain rates by a similar margin. Weekly adalimumab, one of the older drugs, was instead linked to more fatigue in its trials. For most other symptoms, the older drugs showed no statistically significant benefit, giving ustekinumab a clearer edge in this analysis.
Catalog record
| CREATOR | Mao-xuan Lin, Ye-xin Chen, Tu-nan Ding, Wei Han, Mo-han Sun, Yi-yu Dong, Zi-qing Zheng, Yan Zhao, Yi-wen Hu, Run-dong Yu, Yao-fu Zhang, Jun Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |