Treatment of obesity with liraglutide in bipolar disorder: a case report
Salvatore Cipolla, Giovanni Vasca, Daniele De Francesco, Sarah Lombardo, Grazia Delle Femine, Antonio Volpicelli, Francesco Perris, Gaia Sampogna, Mario Luciano · 2026
Read Treatment of obesity with liraglutide in bipolar disorder: a case report by Salvatore Cipolla, Giovanni Vasca, Daniele De Francesco, Sarah Lombardo, Grazia Delle Femine, Antonio Volpicelli, Francesco Perris, Gaia Sampogna, Mario Luciano (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13467832.txt.
Description
Cipolla and colleagues report treating obesity with the drug liraglutide in a 57-year-old man with bipolar I disorder, in a 2026 psychiatric case report. The man had class III obesity with a body mass index of 47.7, insulin resistance, and abnormal blood lipids. His history since 1986 showed manic and depressive relapses across nearly four decades, often triggered by attempts to lose weight. Clinicians therefore started the drug in hospital under close psychiatric monitoring in February 2024.
Liraglutide was raised from 0.6 to 1.8 milligrams over three weeks, and a manic episode followed at the higher dose, scoring 30 on a standard mania scale. Adjusting his other medicines settled the episode within one week. At the target dose of 3 milligrams daily, he lost 7 kilograms in total during follow-up, and his insulin resistance measure improved from 6.19 to 5.78 on the reported index. Mood stayed stable thereafter, a cautiously hopeful outcome.
Catalog record
| CREATOR | Salvatore Cipolla, Giovanni Vasca, Daniele De Francesco, Sarah Lombardo, Grazia Delle Femine, Antonio Volpicelli, Francesco Perris, Gaia Sampogna, Mario Luciano |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |