Animal Models of Idiopathic Inflammatory Myopathies: Bridging Mechanistic Insights and Clinical Translation
Guanyuan Wang, Shaoxin Cui, Lin Yang, Karl J. A. McCullagh, Cuiqing Ma, Aijing Liu · 2026
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Description
Guanyuan Wang and colleagues review in 2026 the animal models used to study idiopathic inflammatory myopathies, a varied family of autoimmune diseases that attack muscle. These diseases differ widely in cause, symptoms, and blood markers, which makes them hard to study and treat. Animal models that copy key features of the human conditions let researchers test disease mechanisms and try therapies before human trials.
The review walks through models for the main subtypes, including T-cell-driven polymyositis-like disease, dermatomyositis, inclusion body myositis, antisynthetase syndrome, and immune-mediated necrotizing myopathy. For each, the authors explain how the model is built, what tissue damage it shows, which immune pathways dominate, and where it has been used to test treatments. The aim is a practical map for choosing the right model for a given research question.
Catalog record
| CREATOR | Guanyuan Wang, Shaoxin Cui, Lin Yang, Karl J. A. McCullagh, Cuiqing Ma, Aijing Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |