A six-gene prognostic signature for aflatoxin B1-associated hepatocellular carcinoma identified through integrated bioinformatics and network toxicology
Chunmei Wang, Jing Li, Yuman Yuan, Lili Liu, Yan He, Bingxi Lei · 2026
Read A six-gene prognostic signature for aflatoxin B1-associated hepatocellular carcinoma identified through integrated bioinformatics and network toxicology by Chunmei Wang, Jing Li, Yuman Yuan, Lili Liu, Yan He, Bingxi Lei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13466791.txt.
Description
Chunmei Wang and colleagues build a six-gene forecast for liver cancer tied to aflatoxin B1, a potent mold toxin in contaminated food, in a 2026 analysis. The toxin is a proven cause of this cancer, above all where diets carry it alongside hepatitis B infection. Gene and clinical records for 377 liver cancer cases came from a public cancer atlas.
Thousands of genes differed between tumor and normal tissue. The team crossed those with predicted toxin targets gathered from three chemical databases, then used network methods to shrink the list to a compact signature. Binding simulations checked how the toxin might grip the signature's proteins. The model aims at prognosis for a cancer subtype that generic tools may fit poorly.
Catalog record
| CREATOR | Chunmei Wang, Jing Li, Yuman Yuan, Lili Liu, Yan He, Bingxi Lei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39563 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |