Estrogen Receptor Beta (ERβ) Expression in Colorectal Cancer (CRC)—A Systematic Review and Meta-Analysis
Yael Sher, Yaron Niv · 2026
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Description
Sher and Niv pooled in 2026 the evidence on estrogen receptor beta in colorectal cancer. This receptor, a protein that responds to the hormone estrogen, sits in healthy colon tissue and may act as a tumor suppressor. Its loss has been tied to advanced disease. The team searched three databases to the end of 2025 for case-control studies. They compared receptor levels in tumor tissue with healthy tissue, and early with late stage tumors.
Sher found only six studies, split into thirteen sub-studies. Receptor presence was far lower in advanced tumors than in healthy tissue or early tumors, with positivity in about half of all-stage tumor samples against about three quarters in the comparison group. Results varied a lot between studies, but dropping any one study did not shake the pattern, and publication bias was not significant. The authors float receptor activation as a possible new treatment route.
Catalog record
| CREATOR | Yael Sher, Yaron Niv |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |