Preliminary exploration of dynamic changes in circulating mitochondrial DNA (ΔmtDNA) as a prognostic biomarker for acute ST-segment elevation myocardial infarction patients: a prospective observational study
Shipeng Tian, Lili Wang, Dongxiao Wang, Shiru Bai, Xian Wang · 2026
Read Preliminary exploration of dynamic changes in circulating mitochondrial DNA (ΔmtDNA) as a prognostic biomarker for acute ST-segment elevation myocardial infarction patients: a prospective observational study by Shipeng Tian, Lili Wang, Dongxiao Wang, Shiru Bai, Xian Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13466647.txt.
Description
Tian and co-authors tested in 2026 whether change in loose mitochondrial DNA in blood around heart attack treatment predicts later trouble. Mitochondria are the cell's power plants; their DNA leaks out when heart muscle dies. The team measured levels before and after emergency artery opening in 236 patients, followed them one year, and grouped them by how much their level changed.
Events were common: 58 patients, about a quarter, suffered a major cardiovascular event within the year. Risk climbed steadily with the size of the DNA change. Each standard step up in change meant roughly a quarter more risk, and the highest-change third fared worst, a clean dose-response pattern. The signal came mostly from returning chest pain rather than deaths or new heart attacks. The authors call the marker exploratory: it may flag patients headed for symptom flare-ups, but must still prove itself against established risk scores.
Catalog record
| CREATOR | Shipeng Tian, Lili Wang, Dongxiao Wang, Shiru Bai, Xian Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |