Epigenetic Mechanisms in Sepsis-Induced Cardiomyopathy: From Pathophysiology to Therapeutic Targets
Chen Jiang, Zhanfei Li, Xijie Dong, Yuchang Wang, Xiaoxuan Zhong, Kan Wang · 2026
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Description
Chen Jiang and colleagues review how gene-control marks shape the heart failure that can follow severe infection, in a 2026 article on sepsis-induced cardiomyopathy. The condition weakens the heart suddenly during sepsis, often reversibly, yet no therapy targets its mechanism. Inflammation, vessel leakage, oxidative stress, and energy failure inside heart cells all contribute.
Gene-control layers may explain why the heart's program stays altered after the infection peaks. The review covers DNA methylation, histone changes, and regulation by small non-coding RNAs in both heart muscle and its immune surroundings. Each mechanism is also judged as a possible treatment target, which is the authors' stated path from description toward therapy.
Catalog record
| CREATOR | Chen Jiang, Zhanfei Li, Xijie Dong, Yuchang Wang, Xiaoxuan Zhong, Kan Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |