Transcriptome and Metabolome Dissection of Multilayered Pydiflumetofen Resistance Mechanisms in Fusarium graminearum
Yun Wang, Dongmei Liu, Haiyan Yin, Cheng Cao, Yingni Cao, Dan Feng, Guanghua Zhao, Junyan Wang, Hongxia Shang, Hongqi Wang, Jihong Liu · 2026
Read Transcriptome and Metabolome Dissection of Multilayered Pydiflumetofen Resistance Mechanisms in Fusarium graminearum by Yun Wang, Dongmei Liu, Haiyan Yin, Cheng Cao, Yingni Cao, Dan Feng, Guanghua Zhao, Junyan Wang, Hongxia Shang, Hongqi Wang, Jihong Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13466391.txt.
Description
Yun Wang and a large team dissect how a wheat head blight fungus resists a newer fungicide, using gene and chemical profiling together, in a 2026 study. The fungus Fusarium graminearum devastates wheat worldwide, and the drug pydiflumetofen blocks one of its energy enzymes. One field-gathered resistant strain was compared against a sensitive one.
The resistant strain carried paired changes in two subunits of the target enzyme, which kept its energy output and drug resistance stable without visible fitness cost. In the sensitive strain, spraying crashed enzyme activity, energy stores, and toxin output while cell membranes leaked. Wide profiling showed layered defenses beyond the target changes, which the authors map for resistance watchers.
Catalog record
| CREATOR | Yun Wang, Dongmei Liu, Haiyan Yin, Cheng Cao, Yingni Cao, Dan Feng, Guanghua Zhao, Junyan Wang, Hongxia Shang, Hongqi Wang, Jihong Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |