BIN1 gain-of-function in the presynaptic compartment leads to isoform-specific synaptotoxicity
Erwan Lambert, Carla Gelle, Valentin Leclerc, Alejandra Freire-Regatillo, Lucie Liefooghe, Nicolas Barois, Tommy Malfoi, Xavier Hermant, Florie Demiautte, Inès Gallienne, Frank Lafont, Philippe Amouyel, Karine Blary, Sabine Kuenen, Chloé Najdek, Patrik Verstreken, Dolores Siedlecki-Wullich, Pierre Y · 2026
Read BIN1 gain-of-function in the presynaptic compartment leads to isoform-specific synaptotoxicity by Erwan Lambert, Carla Gelle, Valentin Leclerc, Alejandra Freire-Regatillo, Lucie Liefooghe, Nicolas Barois, Tommy Malfoi, Xavier Hermant, Florie Demiautte, Inès Gallienne, Frank Lafont, Philippe Amouyel, Karine Blary, Sabine Kuenen, Chloé Najdek, Patrik Verstreken, Dolores Siedlecki-Wullich, Pierre Y (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13466144.txt.
Description
Erwan Lambert tested BIN1 forms in 2026 for synapse toxicity in Alzheimer's disease, where early synapse loss tracks memory decline. BIN1 is a major Alzheimer risk gene with several forms, yet form effects at synapses were undefined. Fly light cells and motor neurons plus rat brain neurons in tiny-channel chambers mapped structure and function by form and cell part.
Only form 1, not forms 8 or 9, caused early signal loss in fly light cells, with oversized vesicles hinting at cell traffic jams. Boosting Rab11 rescued that toxicity, while motor neuron change followed a separate path. In rat neurons, form 1 cut links only from the sending side, pinpointing where this Alzheimer gene first harms synapses.
Catalog record
| CREATOR | Erwan Lambert, Carla Gelle, Valentin Leclerc, Alejandra Freire-Regatillo, Lucie Liefooghe, Nicolas Barois, Tommy Malfoi, Xavier Hermant, Florie Demiautte, Inès Gallienne, Frank Lafont, Philippe Amouyel, Karine Blary, Sabine Kuenen, Chloé Najdek, Patrik Verstreken, Dolores Siedlecki-Wullich, Pierre Y |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |