Comparative efficacy and safety of transcatheter edge-to-edge repair versus tricuspid valve replacement versus optimal medical therapy in moderate-to-severe tricuspid regurgitation: a network meta-analysis of randomized controlled trials
Ihsan Noushad Karuppan Veettil, Anuhya Jamandlamudi, Nebeela Abdul Khader, Tea Shehu, Doris Lacej, Shivangi Jha, Obawole Mayowa, Joshua Zumba, Temirlan Ismailov, Zhanel Almaganbetova, Bertha Gabriela, Lina Hajjar, Sifat Ullah Safi, Muneeb Khawar · 2026
Read Comparative efficacy and safety of transcatheter edge-to-edge repair versus tricuspid valve replacement versus optimal medical therapy in moderate-to-severe tricuspid regurgitation: a network meta-analysis of randomized controlled trials by Ihsan Noushad Karuppan Veettil, Anuhya Jamandlamudi, Nebeela Abdul Khader, Tea Shehu, Doris Lacej, Shivangi Jha, Obawole Mayowa, Joshua Zumba, Temirlan Ismailov, Zhanel Almaganbetova, Bertha Gabriela, Lina Hajjar, Sifat Ullah Safi, Muneeb Khawar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13465960.txt.
Description
Karuppan Veettil and colleagues pooled the trial evidence in 2026 for two catheter fixes of a leaky tricuspid valve, the heart valve that guards the right side. One repair clips the valve edges together; the other replaces the valve outright. Both were compared with drugs alone. Only three randomized trials existed by late 2025, covering 1,050 patients in total. No trial compared the two devices head to head.
Neither device cut overall deaths compared with drugs. Both clearly improved daily function, though. The replacement valve more than tripled the chance of a better symptom class, needing only two patients treated per success. The clip roughly halved that gain. Quality-of-life scores rose past the meaningful threshold on both devices. The costs were extra major bleeding and, for the replacement, far more pacemakers. The authors call for direct head-to-head trials.
Catalog record
| CREATOR | Ihsan Noushad Karuppan Veettil, Anuhya Jamandlamudi, Nebeela Abdul Khader, Tea Shehu, Doris Lacej, Shivangi Jha, Obawole Mayowa, Joshua Zumba, Temirlan Ismailov, Zhanel Almaganbetova, Bertha Gabriela, Lina Hajjar, Sifat Ullah Safi, Muneeb Khawar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |