Antineoplastic and Immunomodulatory Effects of Cabozantinib in Continuous and Primary Human Anaplastic Thyroid Cancer Cells †
Giusy Elia, Silvia Martina Ferrari, Eugenia Balestri, Chiara Botrini, Francesca Ragusa, Valeria Mazzi, Licia Rugani, Simona Piaggi, Elena Catania Romizi, Oriana Fabrazzo, Eleonora Giorgetti, Alessia Baglini, Gilda Varricchi, Camilla Virili, Salvatore Ulisse, Gabriele Materazzi, Alessandro Antonelli, Poupak Fallahi · 2026
Read Antineoplastic and Immunomodulatory Effects of Cabozantinib in Continuous and Primary Human Anaplastic Thyroid Cancer Cells † by Giusy Elia, Silvia Martina Ferrari, Eugenia Balestri, Chiara Botrini, Francesca Ragusa, Valeria Mazzi, Licia Rugani, Simona Piaggi, Elena Catania Romizi, Oriana Fabrazzo, Eleonora Giorgetti, Alessia Baglini, Gilda Varricchi, Camilla Virili, Salvatore Ulisse, Gabriele Materazzi, Alessandro Antonelli, Poupak Fallahi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13465927.txt.
Description
Giusy Elia and a large team test the drug cabozantinib against anaplastic thyroid cancer cells in the lab, reporting in 2026. This cancer grows fast and resists most treatments, and the drug already holds approval for a slower thyroid cancer type. No earlier study had checked its combined cancer-fighting and immune effects in this setting.
Cultures came from two sources: long-kept cell lines and fresh cells taken directly from five patients, which keep more of the original tumor's character. The drug showed clear activity against tumor growth in both kinds of culture. It also shifted immune-related behavior in the cells, a dual effect the authors say could support more personal treatment choices.
Catalog record
| CREATOR | Giusy Elia, Silvia Martina Ferrari, Eugenia Balestri, Chiara Botrini, Francesca Ragusa, Valeria Mazzi, Licia Rugani, Simona Piaggi, Elena Catania Romizi, Oriana Fabrazzo, Eleonora Giorgetti, Alessia Baglini, Gilda Varricchi, Camilla Virili, Salvatore Ulisse, Gabriele Materazzi, Alessandro Antonelli, Poupak Fallahi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33111 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |