Signaling Through Girdin Underlies Excessive Cell Morphogenesis Resulting from Depletion of Neurodevelopmental Disorder-Related Neurexin-2
Hideji Yako, Mikito Takahashi, Mami Akiyama, Ayaka Suzuki, Yuki Miyamoto, Junji Yamauchi · 2026
Read Signaling Through Girdin Underlies Excessive Cell Morphogenesis Resulting from Depletion of Neurodevelopmental Disorder-Related Neurexin-2 by Hideji Yako, Mikito Takahashi, Mami Akiyama, Ayaka Suzuki, Yuki Miyamoto, Junji Yamauchi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13465888.txt.
Description
Hideji Yako and colleagues probe what happens inside young neurons when a docking protein linked to autism and intellectual disability runs low, in a 2026 cell study. The protein, neurexin-2, sits at nerve endings and along growing fibers, guiding how neurons take shape. The team lowered its levels in a neuron-like cell line known for sprouting processes.
Cells with less neurexin-2 grew unusually long processes. A signaling partner called Girdin carried much of that effect, since blocking its pathway trimmed the overgrowth back. The tool used to silence the gene edits RNA rather than DNA, letting the group test cause and effect cleanly. Findings sketch one route from a missing surface protein to misshapen developing neurons.
Catalog record
| CREATOR | Hideji Yako, Mikito Takahashi, Mami Akiyama, Ayaka Suzuki, Yuki Miyamoto, Junji Yamauchi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30675 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |