MANagement of Gallstone disease in the Older patient (MANGO): clinical and quality of life outcomes from a prospective multicentre cohort study
Anna E. Fairclough, Ana D. Gavrila, Charlotte Cossins, Simon K. C. Toh, Alexander R. Darbyshire, Amy Lord, Ayman Darwich, Ayman Darwich, Louise Finch, Atilla Emin, Charlotte Parfitt, Malcolm West, John Primrose, Charles West, Oliver Pickering, Vikash Dodhia, Charlotte Parfitt, Raymond Chaorui Li, Al · 2026
Read MANagement of Gallstone disease in the Older patient (MANGO): clinical and quality of life outcomes from a prospective multicentre cohort study by Anna E. Fairclough, Ana D. Gavrila, Charlotte Cossins, Simon K. C. Toh, Alexander R. Darbyshire, Amy Lord, Ayman Darwich, Ayman Darwich, Louise Finch, Atilla Emin, Charlotte Parfitt, Malcolm West, John Primrose, Charles West, Oliver Pickering, Vikash Dodhia, Charlotte Parfitt, Raymond Chaorui Li, Al (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13465662.txt.
Description
Fairclough and a large trainee-led team ran the MANGO cohort study in 2026 on gallstone disease in older patients. Nine NHS hospitals enrolled consecutive emergency admissions aged 70 and over between 2022 and 2024. Of 194 patients, 36 had emergency gallbladder removal. The other 158 were managed without an operation at first, and they carried more illness and frailty. Quality of life was tracked to one year.
Surgery patients did strikingly better on gallstone-specific outcomes. Gallstone-related readmission at one year hit 23 percent in the non-operative group against about 3 percent after surgery. One-year mortality was about 12 percent against zero, though that gap missed firm statistical ground. All emergency operations began keyhole-style with one conversion and no major complications. Hospital stays were similar. Quality-of-life scores favored surgery at thirty days and remained higher at one year, near 124 against about 116.
Catalog record
| CREATOR | Anna E. Fairclough, Ana D. Gavrila, Charlotte Cossins, Simon K. C. Toh, Alexander R. Darbyshire, Amy Lord, Ayman Darwich, Ayman Darwich, Louise Finch, Atilla Emin, Charlotte Parfitt, Malcolm West, John Primrose, Charles West, Oliver Pickering, Vikash Dodhia, Charlotte Parfitt, Raymond Chaorui Li, Al |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |