Associations of cumulative exposure and dynamic trajectories of the combined atherogenic and frailty index with incident cardiometabolic multimorbidity: a longitudinal analysis based on the China Health and Retirement Longitudinal Study (CHARLS)

Description

Feng and co-authors combined two risk measures into one index in 2026 and tested it against future disease in China. The parts are a blood-fat-based atherogenic index and a frailty index counting health deficits. Multiplied together, they form the AIPFI. Data came from a national aging study with 7,995 participants at baseline. A subgroup of 4,483 had repeat measures three years apart.

Over a median follow-up of nine years, 747 participants, about nine percent, developed cardiometabolic multimorbidity. That means multiple heart and metabolic diseases together. Risk climbed steadily across quarters of the index. The top quarter carried about two and a half times the risk of the bottom quarter after adjustment. People whose index stayed high and rose fared worse too, with about half again the risk. Hypertension, heart disease, and the index itself were the strongest signals in the prediction model.

Catalog record

Source: https://europepmc.org/articles/PMC13465527