Rhynchophylline rewires DLAT lipoylation via conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury
Xiaomin Liang, Xunfang Yang, Shuhui Wang, Fangfang Zhuo, Xingzi Hou, Pengfei Tu, Yang Liu, Kewu Zeng, Qingying Zhang · 2026
Read Rhynchophylline rewires DLAT lipoylation via conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury by Xiaomin Liang, Xunfang Yang, Shuhui Wang, Fangfang Zhuo, Xingzi Hou, Pengfei Tu, Yang Liu, Kewu Zeng, Qingying Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13464090.txt.
Description
Xiaomin Liang and eight co-authors test a plant alkaloid, rhynchophylline, as a guard for dopamine neurons in Parkinson's disease. The compound comes from Uncaria plants, long used in herbal practice. Screens for heat-shifted proteins pointed to DLAT, a core part of the cell's fuel-burning machinery, as its direct target.
The compound latches onto DLAT's head segment and pries it away from a partner enzyme that holds it back. Freed DLAT gains a fatty tag that keeps fuel burning strong and mitochondria whole. Mice missing DLAT lost all benefit from the compound. In two mouse models of the disease, dosing eased movement faults and spared dopamine neurons.
Catalog record
| CREATOR | Xiaomin Liang, Xunfang Yang, Shuhui Wang, Fangfang Zhuo, Xingzi Hou, Pengfei Tu, Yang Liu, Kewu Zeng, Qingying Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71439 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |