Murine T Cell‐Dependent Response Affects Leishmania amazonensis Amastigote Survival and Virulence
Gustavo Henrique Corrêa Soares, Gustavo Rolim Barbosa, Beatriz Simonsen Stolf · 2026
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Description
Soares, Barbosa, and Stolf ask whether a host's immune response can change a parasite's strength in this 2026 study. The parasite, Leishmania amazonensis, causes skin disease and lives inside host cells in a form called the amastigote. The team compared parasites taken from normal mice with those from nude mice, a strain that lacks T cells, the immune cells that coordinate attacks on invaders.
Both mouse groups were infected for 13 weeks before parasites were collected from footpad lesions. Parasites from normal mice survived better and multiplied more once cultured. They also infected cells more aggressively, forming larger internal compartments, and caused stronger disease when placed into new hosts. The authors conclude that living under T-cell pressure had, paradoxically, produced hardier and more virulent parasites.
Catalog record
| CREATOR | Gustavo Henrique Corrêa Soares, Gustavo Rolim Barbosa, Beatriz Simonsen Stolf |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |