Diagnostic value of PSA-based markers in prostate cancer: a retrospective analysis stratified by body mass index
Tao Yang, Qiang Zhang, Ziyang Liu, Jia Tian, Xiaohua Hu, Zhiyong Lv · 2026
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Description
Yang and co-authors asked in 2026 whether body weight distorts PSA blood tests for prostate cancer. Larger blood volume in heavier men can dilute the marker. The team reviewed 663 patients, split into leaner and heavier groups at a body mass index of 24. Standard PSA measures were compared with a new age-adjusted density measure. The new measure also accounts for prostate size.
The age-adjusted measure won in both groups. Among leaner men it scored about seven tenths on the standard accuracy curve scale. Ordinary density scored lower, and total PSA barely beat chance. Among heavier men the new measure scored higher still, near eight tenths. It again beat both older markers, and the differences were statistically firm. A variable-selection method kept choosing the new measure as a core predictor in both groups. That supports its use when deciding who needs a biopsy.
Catalog record
| CREATOR | Tao Yang, Qiang Zhang, Ziyang Liu, Jia Tian, Xiaohua Hu, Zhiyong Lv |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |