Increased sensitivity of the updated FluoroType MTBDR V2 with addition of IS6110 analysis
Erik Svensson, Dorte Bek Folkvardsen, Anders Norman, Erik Michael Rasmussen, Troels Lillebaek · 2026
Read Increased sensitivity of the updated FluoroType MTBDR V2 with addition of IS6110 analysis by Erik Svensson, Dorte Bek Folkvardsen, Anders Norman, Erik Michael Rasmussen, Troels Lillebaek (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13463815.txt.
Description
Erik Svensson and four co-authors test an upgraded molecular assay for tuberculosis, the FluoroType MTBDR. The older version read one gene target and missed cases that rival tests caught. The update adds IS6110, a stretch that appears many times in the germ genome, to lift detection.
In a head-to-head trial on 1,483 patient specimens, the new version caught eighty-seven percent of true cases against seventy percent for the old one. Gains ran largest in specimens where germs were too few to see under the microscope. False alarms stayed rare and equal for both versions. Drug resistance calls, based on unchanged targets, gained little from the update.
Catalog record
| CREATOR | Erik Svensson, Dorte Bek Folkvardsen, Anders Norman, Erik Michael Rasmussen, Troels Lillebaek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28581 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |