Mitral valve posteromedial papillary muscle head rupture presenting after liposomal doxorubicin chemotherapy for metastatic lung liposarcoma: a case report
Shivam U Desai, Narayana R Gandham · 2026
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Description
Desai and Gandham describe in this 2026 case report a rare form of chemotherapy heart damage: a torn heart valve support structure in a patient whose heart muscle strength looked normal. The patient was a 78-year-old woman with metastatic liposarcoma, a soft-tissue cancer, treated with a liposomal form of the drug doxorubicin.
One week after finishing treatment, at a cumulative dose of 534 milligrams, she developed sudden breathlessness. Ultrasound imaging through the esophagus showed the head of a papillary muscle, one of the anchors holding the mitral valve shut, had ruptured, causing severe valve leakage. Her ejection fraction had stayed between 65 and 75 percent on scans from 2022 to 2025, so standard monitoring missed the danger. The authors propose a two-hit explanation combining drug injury with earlier lung radiation near the heart.
Catalog record
| CREATOR | Shivam U Desai, Narayana R Gandham |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |