Apical proximal tubule fatty acid uptake–generated ceramides cause endoplasmic reticulum stress from altered membrane fluidity
Zhiyu Liu, Robert J Gaivin, Shenaz Khan, Vincent Li, Amal Chaba, Fraser J Moss, Usman Sabir, Takhar Kasumov, Tingwei Mu, Jeffrey R Schelling · 2026
Read Apical proximal tubule fatty acid uptake–generated ceramides cause endoplasmic reticulum stress from altered membrane fluidity by Zhiyu Liu, Robert J Gaivin, Shenaz Khan, Vincent Li, Amal Chaba, Fraser J Moss, Usman Sabir, Takhar Kasumov, Tingwei Mu, Jeffrey R Schelling (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13463616.txt.
Description
Zhiyu Liu and nine co-authors study how fatty acids harm kidney tubule cells when the kidney filter leaks. Healthy tubules take in fatty acids from the blood side and burn them for fuel. In chronic kidney disease, albumin-bound acids slip through the damaged filter and enter from the urine side instead.
Human tubule cells fed palmitate from the urine side switched on stress genes and split their inner stress organelles. The same cells stored fewer fat droplets, and a fat called C16:0 ceramide built up inside them. Blocking ceramide making stopped the stress, while adding ceramide stiffened cell membranes and caused stress on its own. Leaked fat, the work shows, poisons tubules through ceramide rather than through fat load alone.
Catalog record
| CREATOR | Zhiyu Liu, Robert J Gaivin, Shenaz Khan, Vincent Li, Amal Chaba, Fraser J Moss, Usman Sabir, Takhar Kasumov, Tingwei Mu, Jeffrey R Schelling |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52014 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |