A nomogram model for early recognition of acute necrotizing encephalopathy: a retrospective study
Mutian Zheng, Tao Pan, Hongmei Chen, Zhenjiang Bai, Shuiyan Wu, Huiwen Li, Siyu Yang, Qiujiao Zhu · 2026
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Description
Mutian Zheng and colleagues build, in a 2026 records study, a chart-style tool for spotting a rare brain complication in children early. The condition, acute necrotizing encephalopathy, strikes after infections such as flu or COVID-19 and brings a poor outlook. The team studied children who arrived with seizures or disturbed consciousness after those infections at a children's hospital in Soochow between late 2021 and early 2024.
Four signs independently marked children who developed the complication: altered consciousness, plus three blood measures, two liver and tissue enzymes and a kidney waste marker. A scoring chart built from the four sorted cases with high accuracy in the building group and a held-back check group. Calibration and decision analyses supported its accuracy for flagging risk. The authors offer the chart as a way to catch high-risk children sooner and start care, while noting it needs testing at other hospitals before wide use.
Catalog record
| CREATOR | Mutian Zheng, Tao Pan, Hongmei Chen, Zhenjiang Bai, Shuiyan Wu, Huiwen Li, Siyu Yang, Qiujiao Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24396 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |