High SRD5A2 expression is associated with poor prognosis and promotes tumor cell progression in colorectal cancer
Meng-Fan Jia, Meng-Nan Dai, Kai-Ye Hua, Si-Yuan Du, Jian Lu, Ying-Wei Zhu · 2026
Read High SRD5A2 expression is associated with poor prognosis and promotes tumor cell progression in colorectal cancer by Meng-Fan Jia, Meng-Nan Dai, Kai-Ye Hua, Si-Yuan Du, Jian Lu, Ying-Wei Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13462557.txt.
Description
Meng-Fan Jia leads a 2026 study of an enzyme called SRD5A2 in colorectal cancer. The enzyme converts testosterone into a stronger form, dihydrotestosterone, and plays roles in sex development. Its profile in bowel cancer was poorly known. The team studied samples from 180 patients, sorting them by enzyme level, and silenced the gene in cancer cells to test growth.
Enzyme levels ran higher in tumors than in normal tissue nearby. High levels went with worse traits and shorter survival, standing as an independent risk factor after adjustment. The link held across most stage subgroups. In dishes, silencing the enzyme slowed growth, movement, and invasion while raising cell death. Protein tests showed shifts in the shape-changing program that frees cancer cells, in growth pathways, and in the cells' energy balance. The authors name SRD5A2 a driver and marker in colorectal cancer.
Catalog record
| CREATOR | Meng-Fan Jia, Meng-Nan Dai, Kai-Ye Hua, Si-Yuan Du, Jian Lu, Ying-Wei Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50778 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |