ALOX12 suppresses colon cancer progression by promoting p53-mediated ferroptosis through upregulating ROS-induced stress
Junjie Wu, Congxing Liu, Yaya Sun, Guangqing Jiang, Yupeng Zhao, Yihong Zhang, Yiping Yin, Xin Shi · 2026
Read ALOX12 suppresses colon cancer progression by promoting p53-mediated ferroptosis through upregulating ROS-induced stress by Junjie Wu, Congxing Liu, Yaya Sun, Guangqing Jiang, Yupeng Zhao, Yihong Zhang, Yiping Yin, Xin Shi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13462342.txt.
Description
Junjie Wu leads a 2026 study showing that an enzyme, ALOX12, restrains colon cancer. It helps the protein p53 kill tumor cells through ferroptosis, an iron-driven form of cell death marked by fat damage. Colon cancer is varied and its toll keeps rising. ALOX12 was known to matter for p53-driven ferroptosis, yet its role in colon tumors was open. The team profiled it in tissue and cell lines, then tested it in dishes and animals.
ALOX12 ran low in colon tumors, and low levels marked worse outlook. Restoring the enzyme slowed cell growth and tumor formation by raising oxygen stress. Boosted ALOX12 made cancer cells more sensitive to ferroptosis, in a form needing active p53 and oxygen stress. The chain works: p53 suppresses a partner gene, SLC7A11, freeing ALOX12 to act. The authors propose ALOX12 as a marker of better outlook and a treatment lever for colon cancer.
Catalog record
| CREATOR | Junjie Wu, Congxing Liu, Yaya Sun, Guangqing Jiang, Yupeng Zhao, Yihong Zhang, Yiping Yin, Xin Shi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |