Response‐adapted consolidation and salvage strategies in secondary central nervous system lymphoma: Insights from a multicentre cohort
Farina Eigendorff, Fabian Görke, Vanja Zeremski, Sophia Wollnitza, Evgenii Shumilov, Georg Lenz, Ellen Obstfelder, Inken Hilgendorf, Vladan Vučinić, Andreas Hochhaus, Ulf Schnetzke · 2026
Read Response‐adapted consolidation and salvage strategies in secondary central nervous system lymphoma: Insights from a multicentre cohort by Farina Eigendorff, Fabian Görke, Vanja Zeremski, Sophia Wollnitza, Evgenii Shumilov, Georg Lenz, Ellen Obstfelder, Inken Hilgendorf, Vladan Vučinić, Andreas Hochhaus, Ulf Schnetzke (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13461960.txt.
Description
Farina Eigendorff leads a 2026 multi-center study of lymphoma spread into the brain and spinal cord, a rare turn of aggressive lymphoma. Few forward-looking studies guide care. The team gathered records for 105 adults treated at four university centers between 2016 and 2024. Treatment order, response, and outcomes were captured in detail to find what supports lasting control.
Median time before regrowth was under eight months, and median survival was under seventeen months. A consolidation step using high-dose chemotherapy and transplant of the patient's stem cells went with clearly better survival, in simple and adjusted analyses. Reaching full remission before that transplant mattered most. In a small group whose disease returned or resisted care, engineered immune cell therapy aimed at the marker CD19 gave better results than other rescue care in early analysis. The authors offer the findings as benchmarks for planning treatment by risk.
Catalog record
| CREATOR | Farina Eigendorff, Fabian Görke, Vanja Zeremski, Sophia Wollnitza, Evgenii Shumilov, Georg Lenz, Ellen Obstfelder, Inken Hilgendorf, Vladan Vučinić, Andreas Hochhaus, Ulf Schnetzke |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43181 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |