Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma: a population-based retrospective study using SEER data

Description

Linwei Zhuang and colleagues describe, in a 2026 population study, a rare lung cancer called pulmonary spindle cell carcinoma, named for its stretched cell shape. It makes up well under one percent of lung cancers, so its traits and outlook were poorly mapped. The team used a US cancer registry covering diagnoses from 2004 to 2014.

The strict group held 250 patients, compared against over two hundred thousand other lung cancer patients. Median age was 72, just over half were men, and nearly half had distant spread at diagnosis. Tumors were larger and less well formed than other lung cancers. Median survival was a few months, and few patients lived five years. Female sex, lower stage, surgery, and chemotherapy each went with longer cancer-specific survival. A prediction model built from the data sorted risk well. The authors caution treatment links are not proof of benefit, since care was not assigned at random.

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Source: https://europepmc.org/article/MED/PMC13461948