Splicing factor mutations clearance and outcomes in clonal myeloid neoplasms: a referral center experience
Manasawee Tanariyakul, Sarah Mott, Bethany Daniels, Avani Yaganti, Chalothorn Wannaphut, Sarah Hornberg, Prajwal Dhakal, Grerk Sutamtewagul, Kittika Poonsombudlert · 2026
Read Splicing factor mutations clearance and outcomes in clonal myeloid neoplasms: a referral center experience by Manasawee Tanariyakul, Sarah Mott, Bethany Daniels, Avani Yaganti, Chalothorn Wannaphut, Sarah Hornberg, Prajwal Dhakal, Grerk Sutamtewagul, Kittika Poonsombudlert (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13461927.txt.
Description
Manasawee Tanariyakul and co-authors asked whether erasing splicing factor mutations from the blood predicts better outcomes in myeloid blood cancers, or merely reflects treatment received. These gene changes drive myelodysplastic syndromes and some leukemias but rarely act alone. In their 2026 review, ninety five adults treated at a referral center from 2016 to 2025 were tracked for clearance, remission, transplantation, and survival. Fifty seven had acute myeloid leukemia.
The changes became undetectable in twenty two leukemia patients and eight in the MDS group after treatment. In leukemia, clearance tracked with receiving a stem cell transplant but not with remission or survival. In MDS, clearance tracked with remission but again not with survival or transplant receipt. Median survival actually ran numerically longer for the persistent group in MDS, 23.7 against 16.7 months in the comparison reported. Clearance is a weak leftover disease marker here.
Catalog record
| CREATOR | Manasawee Tanariyakul, Sarah Mott, Bethany Daniels, Avani Yaganti, Chalothorn Wannaphut, Sarah Hornberg, Prajwal Dhakal, Grerk Sutamtewagul, Kittika Poonsombudlert |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |