Linear dose-response relationship between vancomycin trough concentration and acute kidney injury in sepsis: effect modification by hyperlactatemia
Jing Tang, Daiyu Shen, Xun Zhou, Ling Xiao, Xinzhu Yuan, Bo Hu · 2026
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Description
Jing Tang and co-authors examine, in a 2026 records study, how the lowest blood level of vancomycin relates to kidney injury in patients with sepsis. Vancomycin levels are checked to guide dosing. The team used a multi-hospital intensive care database. Adults with sepsis who received the drug into a vein and had a trough level measured were included, unless already injured.
Among 946 patients, about one in ten developed kidney injury. After accounting for other factors, each rise in the first trough level came with higher odds of kidney injury, in a straight-line pattern with no safe cut-off. The top band carried several times the risk of the lowest band. High lactate, a marker of poor tissue supply, sharpened the link. Risk rose there and barely at all when lactate was normal. The authors advise extra caution with drug levels when lactate is high.
Catalog record
| CREATOR | Jing Tang, Daiyu Shen, Xun Zhou, Ling Xiao, Xinzhu Yuan, Bo Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |