Elranatamab Population Pharmacokinetics and Exposure–Response for Cytokine Release Syndrome in Patients with Relapsed or Refractory Multiple Myeloma
Jennifer E Hibma, Donald Irby, Alan Liu, Mohamed Elmeliegy, Lindsay E King, David Gifondorwa, Sibo Jiang, Kamrine E Poels, Pooneh Soltantabar, Hoi-Kei Lon, Blerta Shtylla, Diane Wang, Jason H Williams, Timothy Nicholas · 2026
Read Elranatamab Population Pharmacokinetics and Exposure–Response for Cytokine Release Syndrome in Patients with Relapsed or Refractory Multiple Myeloma by Jennifer E Hibma, Donald Irby, Alan Liu, Mohamed Elmeliegy, Lindsay E King, David Gifondorwa, Sibo Jiang, Kamrine E Poels, Pooneh Soltantabar, Hoi-Kei Lon, Blerta Shtylla, Diane Wang, Jason H Williams, Timothy Nicholas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13461831.txt.
Description
Jennifer E Hibma leads a 2026 drug modeling study of elranatamab, a lab-made antibody for multiple myeloma that has returned or stopped responding. The drug grabs two targets at once, one on cancer cells and one on immune cells, pulling them to attack the tumor. The team built a population model of drug movement through the body. Data came from four studies with 321 people.
Over thirteen thousand measurements fed the model, covering doses given into a vein or under the skin. Drug levels rose in a straight line with dose. Age, sex, weight, and other traits did not shift exposure in ways that mattered. Early peak levels and tumor burden best predicted a flu-like immune reaction that follows the first step-up dose. Simulations backed restarting after breaks of up to twelve weeks without rebuilding the dose, supporting the fixed-dose plan in use.
Catalog record
| CREATOR | Jennifer E Hibma, Donald Irby, Alan Liu, Mohamed Elmeliegy, Lindsay E King, David Gifondorwa, Sibo Jiang, Kamrine E Poels, Pooneh Soltantabar, Hoi-Kei Lon, Blerta Shtylla, Diane Wang, Jason H Williams, Timothy Nicholas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67161 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |