Comparative genomics reveals immunomodulatory and anti-obesity traits of Lactococcus lactis subsp. lactis
Huijin Jeong, Hyukjoon Choi, Young-Seo Park · 2026
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Description
Huijin Jeong and co-authors sequenced two strains of the dairy bug Lactococcus lactis to find the genes behind their reported immune calming and anti obesity effects. Probiotic claims are strain specific, so a genome level audit is the first credibility test. In their 2026 study, the strains CAB701 and WiKim0124 were sequenced and confirmed as the same subspecies by standard identity metrics. They were aligned against reference genomes and mined for useful genes and unique gene clusters.
Both genomes aligned closely with references, showing high structural agreement with only minor variations. Annotation surfaced genes for carbohydrate use, biofilm formation, and immune calming. The pan genome contained a substantial strain specific fraction indicating niche adaptation. Most notably, both strains carry unique clusters for making nisin Z and sactipeptides, molecules that plausibly underpin immune effects. Genes for short chain fatty acid metabolism were also present.
Catalog record
| CREATOR | Huijin Jeong, Hyukjoon Choi, Young-Seo Park |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |