MiRNA-140-3p affects the proliferation and metastasis of osteosarcoma via the UBE2C/PI3K-Akt axis
Xu Yang, Yubo Xiang, Haoran Liu, Zhengchen Li, Zheng Luo, Jia Liu, Yongxin Bao, Yingxin Yang · 2026
Read MiRNA-140-3p affects the proliferation and metastasis of osteosarcoma via the UBE2C/PI3K-Akt axis by Xu Yang, Yubo Xiang, Haoran Liu, Zhengchen Li, Zheng Luo, Jia Liu, Yongxin Bao, Yingxin Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13461478.txt.
Description
Xu Yang and colleagues traced how a tiny RNA, miR-140-3p, restrains osteosarcoma, the commonest primary bone cancer of the young. The RNA runs low in osteosarcoma cells, and patients with low levels survive more poorly, the team found.
Single-cell data and database survival analyses guided the experiments. Boosting the RNA in dish and mouse tests slowed tumour growth and spread, stalled the cell cycle, and pushed cancer cells to die. Cutting it had the opposite effect, speeding growth and lung spread in mice. The RNA works by silencing a gene called UBE2C, which feeds a growth pathway named PI3K-Akt. Yang proposes this three-part axis as a treatment target for osteosarcoma.
Catalog record
| CREATOR | Xu Yang, Yubo Xiang, Haoran Liu, Zhengchen Li, Zheng Luo, Jia Liu, Yongxin Bao, Yingxin Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |