The Tumor-suppressive role of CNTNAP2 in glioma: Dual regulation of the NDN-ERK axis and M2 macrophage polarization
Yu Wu, Weiwei Zou, Shiqi Xia, Ti Zhang, Fan Yao, Yangqin Li, Xiaoqian Liu, Qian Peng, Xiao-Liang Xing · 2026
Read The Tumor-suppressive role of CNTNAP2 in glioma: Dual regulation of the NDN-ERK axis and M2 macrophage polarization by Yu Wu, Weiwei Zou, Shiqi Xia, Ti Zhang, Fan Yao, Yangqin Li, Xiaoqian Liu, Qian Peng, Xiao-Liang Xing (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13461343.txt.
Description
Yu Wu and colleagues investigated in 2026 the gene CNTNAP2 as a brake on glioma, the most lethal brain tumor type. A pan-cancer scan of atlas data showed the gene separates glioma from normal tissue with high accuracy, and patients with low levels survived less long. Experiments in a glioblastoma cell line and in mouse tissue then tested cause rather than correlation.
Removing the gene made cancer cells multiply and move faster, while restoring it slowed them down. Its absence overactivated the ERK growth pathway and shut down a downstream gene called Necdin, and blocking ERK reversed the damage. Low CNTNAP2 also matched heavy infiltration by tumor-friendly M2 macrophages and worse predicted response to immunotherapy, giving the gene diagnostic, prognostic, and treatment interest.
Catalog record
| CREATOR | Yu Wu, Weiwei Zou, Shiqi Xia, Ti Zhang, Fan Yao, Yangqin Li, Xiaoqian Liu, Qian Peng, Xiao-Liang Xing |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41004 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |