AQP4-IgG-positive myelitis occurring in a patient with small cell lung cancer: a case report
Meijian Yang, Dongjie Du, Xiaoci Cao, Jia Liu, Jing Zhao · 2026
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Description
Meijian Yang and colleagues report a lung cancer patient whose spinal cord failure turned out to be autoimmune myelitis, not tumour spread. The 65-year-old man had extensive-stage small cell lung cancer and arrived with bladder failure, then fast-rising leg paralysis.
Scans showed long inflamed stretches inside the cord with no crushing mass, and spinal fluid held inflammation but no cancer cells. Blood and fluid tested strongly positive for AQP4 antibodies, pinning the diagnosis on neuromyelitis optica spectrum disorder. High-dose steroids plus immune globulin steadied him, and a maintenance drug, satralizumab, followed during steroid tapering. Yang urges prompt antibody testing in such cases, since mistaking myelitis for metastasis delays the right treatment.
Catalog record
| CREATOR | Meijian Yang, Dongjie Du, Xiaoci Cao, Jia Liu, Jing Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |