CD8+ T cell activation occurs 24 hours after AAV administration and is driven by muscle promoter specificity
Lindsay Jeanpierre, Coralie Pecquet, Hanadi Saliba, Pauline Finard, Stéphane Terry, Gianni Tavella, Inès Guesmia, Sylvie Boutin, Bérangère Bertin, Sofia Benkhelifa-Ziyyat, Giuseppe Ronzitti, David-Alexandre Gross · 2026
Read CD8+ T cell activation occurs 24 hours after AAV administration and is driven by muscle promoter specificity by Lindsay Jeanpierre, Coralie Pecquet, Hanadi Saliba, Pauline Finard, Stéphane Terry, Gianni Tavella, Inès Guesmia, Sylvie Boutin, Bérangère Bertin, Sofia Benkhelifa-Ziyyat, Giuseppe Ronzitti, David-Alexandre Gross (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13461172.txt.
Description
Lindsay Jeanpierre and co-authors timed the immune system's first response to gene therapy delivered into muscle, finding the alarm sounds within a day. Virus based AAV vectors carry replacement genes, but killer T cells can destroy the corrected cells after sensing the new protein. In their 2026 mouse study, the team tracked viral genomes and gene derived fragments after intramuscular injection. It tested which design features, especially the muscle specific promoter switches, control how much antigen immune sentinels display.
Viral genomes reached the draining lymph nodes within one hour of injection, and gene fragments were being presented to CD8 T cells from day one, with first cell divisions by day four. Removing the injection site still produced full T cell responses, proving the first hour's drainage suffices to launch immunity. Promoters differed in how much they leaked expression into dendritic cells, and leakier designs drove stronger early T cell activation.
Catalog record
| CREATOR | Lindsay Jeanpierre, Coralie Pecquet, Hanadi Saliba, Pauline Finard, Stéphane Terry, Gianni Tavella, Inès Guesmia, Sylvie Boutin, Bérangère Bertin, Sofia Benkhelifa-Ziyyat, Giuseppe Ronzitti, David-Alexandre Gross |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |