Reduced CCL/Be-specific CD4+ T cells in CCL3-deficient or peptide-MHCII CAR-T cell–treated mice
Michael T Falta, Masoom Raza, Caley J Nevienski, Tonya M Brunetti, Rui Fu, Rebecca M Tucker, Joseph M Gaballa, Faiz Minhajuddin, Kibrom M Alula, Alberto Dinarello, Douglas G Mack, Allison K Martin, Joseph C Onyiah, Michael Yarnell, Prashanth Francis, Terry J Fry, Lisa A Maier, Andrew P Fontenot, Cha · 2026
Read Reduced CCL/Be-specific CD4+ T cells in CCL3-deficient or peptide-MHCII CAR-T cell–treated mice by Michael T Falta, Masoom Raza, Caley J Nevienski, Tonya M Brunetti, Rui Fu, Rebecca M Tucker, Joseph M Gaballa, Faiz Minhajuddin, Kibrom M Alula, Alberto Dinarello, Douglas G Mack, Allison K Martin, Joseph C Onyiah, Michael Yarnell, Prashanth Francis, Terry J Fry, Lisa A Maier, Andrew P Fontenot, Cha (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13461158.txt.
Description
Michael T Falta and colleagues show that signals CCL3 and CCL4 drive disease-causing T cells in chronic Be disease in a 2026 mouse study. Be exposure triggers lumpy lung swelling through CD4 T cells spotting Be-modified signal peptides, yet the signals' causal role was unproven. HLA-DP2 gene-changed mice lacking CCL3 and CCL4 were exposed to Be, with lung immune responses, bone marrow mixes and RNA reads compared.
Signal-lacking mice kept normal guard cell and branching cell numbers but showed far fewer total and signal-Be-specific CD4 T cells, IFN-gamma producers and lung clumps. Blood-making branching cells proved the key regulators, and peptide-MHCII CAR-T cells targeting the specific T cells also reduced responses. Experts gain a new clear-out strategy for a disease with few treatment options.
Catalog record
| CREATOR | Michael T Falta, Masoom Raza, Caley J Nevienski, Tonya M Brunetti, Rui Fu, Rebecca M Tucker, Joseph M Gaballa, Faiz Minhajuddin, Kibrom M Alula, Alberto Dinarello, Douglas G Mack, Allison K Martin, Joseph C Onyiah, Michael Yarnell, Prashanth Francis, Terry J Fry, Lisa A Maier, Andrew P Fontenot, Cha |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |